• Felicia is the drunken, psychopathical, and often drugged wife of Mr. Alacrán. She ran off with fellow opium farmer Mr. MacGregor, and comes home with a son, Tom, as a result. As Tom grows up, the two continuously plot Matt's downfall.
  • Tom is a rude, mean-spirited boy who is detested (with varying degrees of openness) by almost everyone at the Alacrán Estate. He has specific animosity towards Matt, whom he and Felicia frequently try to bring down.
  • Benito is one of Mr. Alacrán's children. He is described by Matt as "slightly nicer" than Steven and Emilia, which more or less proves to be true.
  • Fani is Benito's wife. She detests her husband, but was drugged and forced to marry him by El Patrón. She frequently drinks as a form of escapism. She may have been at the funeral and died, or could have possibly left Benito the moment his great-great-grandfather died, as she hated him and El Patrón's power no longer held over her, and she wouldn't have to leave Nigeria.
  • Felipe is El Patrón's son, who has died long before the time of the story's premise.
  • Mr. MacGregor is a drug lord in Opium and El Patrón's apparent best friend. He also invokes the use of a clone for organs, much to the shock of Matt and María.
  • Sister Inez is a nun at the Covenant of Santa Clara, where María and Emilia attend school.
  • Jorge, Raul, and Carlos are Keepers in Aztlan, who frequently mistreat the Lost Boys while they themselves enjoy lavish parties and the use of laudanum, a drug similar to heroin.
  • Furball is Maria's dog, who is later poisoned with laudanum by Felicia to frame Matt.
  • Keepers Keepers are the adult workers who watch over the Lost Boys. Most are mean and cruel to the Lost Boys.
  • Fidelito A skinny child also kept in hand of the Keepers, Matt's friend who help him escapeChacho- Another friend who helps Matt escape, Chacho is Matt's best friend in the plankton factory
  • Ton-Ton is a stuttering but dedicated Lost Boy who becomes very valuable to Matt in his attempt to escape the Keepers and resolve the crisis in Opium.
  • Flaco is another Lost Boy in the Keepers' care, and the oldest in the plankton factory.
  • Mr. Ortega is Matt's (ironically) deaf music teacher.
  • Tam Lin is Matt's bodyguard and father figure. El Patron gives Matt a choice between Tam Lin and Daft Donald, his other bodyguard; Matt sees a "glint of friendliness" in Tam Lin's eyes and chooses him. Matt quickly bonds with Tam Lin, who teaches Matt to climb treacherous rock-faces and live for days in the wild. He is also one of the only people who believes what Matt says about Tom. Tam Lin is later called back to El Patrón's side and leaves Matt with a cache of supplies in the hopes that when El Patrón decides to take Matt's heart for his own, Matt will escape over the nearby mountains into Aztlán to seek out the convent of Santa Clara where María lives and attends school. All of El Patrón's bodyguards are wanted criminals, and Tam Lin is no exception: he was a Scottish nationalist who laid a bomb for the British Prime Minister that accidentally killed a bus full of 20 children instead. As atonement, he drinks wine he knows El Patrón poisoned, along with all of the other Alacráns.
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